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Common (1% to 10%): Peripheral edema, fatigue, edemaIn addition, N-desmethyl metabolite AUC and Cmax values significantly increased by 200% and 79%, respectively in subjects with severe renal impairment compared to subjects with normal renal function.

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July 23, 2027 discount generic cialis Although sildenafil (Viagra), vardenafil (Levitra), and tadalafil (Cialis) all work by inhibiting PDE5, tadalafil's pharmacologic distinction is its longer half-life (17.50 hours) [4] – compared to sildenafil and vardenafil (both 4.0–5.0 hours)[5] – resulting in longer duration of action, and so partly responsible for "The Weekend Pill" sobriquet. Furthermore, the longer half-life is the basis for current investigation of tadalafil's daily therapeutic use in relieving pulmonary arterial hypertension. Sildenafil is approved in several world regions as a thrice-daily therapy for pulmonary arterial hypertension.Nervous: seizure, seizure recurrence, anxiety, and transient global amnesia. Quinidine

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