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Administration of Levitra with nitrates (either regularly and/or intermittently) and nitric oxide donors is contraindicated [see Clinical Pharmacology (12.2)]. Consistent with the effects of PDE5 inhibition on the nitric oxide/cyclic guanosine monophosphate pathway, PDE5 inhibitors, including Levitra, may potentiate the hypotensive effects of nitrates. A suitable time interval following dosing of Levitra for the safe administration of nitrates or nitric oxide donors has not been determined. generic cialis 20mg
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