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Antihypertensives — PDE5 inhibitors, including tadalafil, are mild systemic vasodilators. Clinical pharmacology studies were conducted to assess the effect of tadalafil on the potentiation of the blood-pressure-lowering effects of selected antihypertensive medications (amlodipine, angiotensin II receptor blockers, bendrofluazide, enalapril, and metoprolol). Small reductions in blood pressure occurred following coadministration of tadalafil with these agents compared with placebo. [see Warnings and Precautions (5.6) and Clinical Pharmacology (12.2)].

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Levitra can also cause sudden loss of vision by decreasing the flow of blood to the optic nerve in the eye. This occurrence is mostly exhibited in people suffering from heart disease, high cholesterol, high blood pressure, diabetes or other eye problems, and thus should you be suffering from these, it is essential that you consult your doctor before using the drug. This loss in vision may also occur if you are over 50 years of age and in the habit of smoking regularly.In placebo-controlled clinical studies, the discontinuation rate due to adverse reactions for Viagra (2.5%) was not significantly different from placebo (2.3%).