Administration of this drug with food may increase drug exposure and may increase the rate of side effects (especially nervous system symptoms).[Ref]A 42-year-old HIV-positive woman's saquinavir in her highly active antiretroviral therapy was replaced with this drug to increase compliance. Two weeks after initiation, the patient reported severe and constant burning in her tongue, gums, and oral mucosa and was diagnosed with burning mouth syndrome (BMS). Efavirenz (the active ingredient contained in Sustiva) was discontinued and the BMS resolved within a week.[Ref]Drugs used to treat ADHD target chemicals in the brain known as neurotransmitters. Most of the ADHD medications work by increasing levels of the neurotransmitters dopamine and norepinephrine. Another type of ADHD drug increases the level of norepinephrine only.
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