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Administration of this drug with food may increase drug exposure and may increase the rate of side effects (especially nervous system symptoms).[Ref]

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Information last revised August 2012. Copyright(c) 2012 First Databank, Inc.

A 42-year-old HIV-positive woman's saquinavir in her highly active antiretroviral therapy was replaced with this drug to increase compliance. Two weeks after initiation, the patient reported severe and constant burning in her tongue, gums, and oral mucosa and was diagnosed with burning mouth syndrome (BMS). Efavirenz (the active ingredient contained in Sustiva) was discontinued and the BMS resolved within a week.[Ref]ImmunologicSitagliptin